ea0090p451 | Reproductive and Developmental Endocrinology | ECE2023
Marie Clementine
, Pierre Alice
, Mayeur Anne
, Giton Frank
, Grynberg Michael
, Cohen-Tannoudji Joelle
, Guigon Celine
, Chauvin Stephanie
Estradiol (E2) plays an essential role in woman fertility. E2, locally produced by granulosa cells (GCs) of ovarian antral follicles, controls follicular development and selection, and triggers the gonadotropin surge that leads to ovulation. Dysovulation arising from the arrest of antral follicle growth and maturation occurs in up to 10 % of reproductive-aged women suffering polycystic ovary syndrome (PCOS). Although the diagnostic criteria for PCOS are clearly established, th...